M.Sc. Maria Herbster

M.Sc. Maria Herbster

Projekte

Abgeschlossene Projekte

MEMoRIAL-M2.3 | Evaluation of force contributions to the damage evolution and failure analysis of metallic arthroplasty components
Laufzeit: 01.09.2017 bis 30.04.2022

The incidence of total hip replacements in OECD countries is >300/100.000 inhabitants. Due to the demographic challenge, more than 400.000 total knee and hip arthroplasties are implanted each year (incidence 400/100.000 inhabitants) with numbers being expected to increase. About 5% of these patients are in need of revision surgery due to prosthesis loosening within 10 years.
One main factor contributing to aseptic hip prosthesis loosening is corrosion at the head-neck junction.
Wear and corrosion at this modular junction have been recognized to induce early failure of hip replacements. There have been a number of reports on the occurrence of taper corrosion and/or fretting with some of them conjecturing a link to the occurrence of adverse local tissue reaction specifically with respect to total hip replacement. Factors like manufacturing tolerances, surgical technique, non-axial alignment, material combination, high frictional torque, and high bending moment were identified to affect the failure process.

The objective of this PhD project is to elucidate the effects and contributions mentioned above, aiming for technical improvements to reduce the risk factors. Therefore, this study will mainly focus on the evaluation of the tribological properties and contributing factors.
Damage analysis of explants and simulation of worst case scenarios using test implants will be performed.
To improve the current standard, different material combinations will be investigated to understand relevant (e.g. crevice and bimetallic) corrosion processes. The investigation of biological reactions between tissue and wear particles generated by damaged implants makes up another important part of this sub-project.
This interaction will be analysed in cooperation with the laboratory for experimental orthopedics.
Several analytical methods (e.g. SEM, cell culture, hip simulator testing) will be applied to examine and clarify the interplay of implant wear and human tissue.

The incidence of total hip replacements in OECD countries is >300/100.000 inhabitants. Due to the demographic challenge, more than 400.000 total knee and hip arthroplasties are implanted each year (incidence 400/100.000 inhabitants) with numbers being expected to increase. About 5% of these patients are in need of revision surgery due to prosthesis loosening within 10 years.
One main factor contributing to aseptic hip prosthesis loosening is corrosion at the head-neck junction.
Wear and corrosion at this modular junction have been recognized to induce early failure of hip replacements. There have been a number of reports on the occurrence of taper corrosion and/or fretting with some of them conjecturing a link to the occurrence of adverse local tissue reaction specifically with respect to total hip replacement. Factors like manufacturing tolerances, surgical technique, non-axial alignment, material combination, high frictional torque, and high bending moment were identified to affect the failure process.

The objective of this PhD project is to elucidate the effects and contributions mentioned above, aiming for technical improvements to reduce the risk factors. Therefore, this study will mainly focus on the evaluation of the tribological properties and contributing factors.
Damage analysis of explants and simulation of worst case scenarios using test implants will be performed.
To improve the current standard, different material combinations will be investigated to understand relevant (e.g. crevice and bimetallic) corrosion processes. The investigation of biological reactions between tissue and wear particles generated by damaged implants makes up another important part of this sub-project.
This interaction will be analysed in cooperation with the laboratory for experimental orthopedics.
Several analytical methods (e.g. SEM, cell culture, hip simulator testing) will be applied to examine and clarify the interplay of implant wear and human tissue.

Projekt im Forschungsportal ansehen

Publikationen

2023

Begutachteter Zeitschriftenartikel

In vivo corrosion on retrieved hip endoprostheses and in vitro effects of corrosion products on bone mineralization

Herbster, Maria; Müller, Eva; Jahn, Jannik Benjamin; Buchholz, Adrian; Tootsi, Kaspar; Lohmann, Christoph H.; Halle, Thorsten; Bertrand, Jessica

In: Bone - Amsterdam [u.a.] : Elsevier Science, Bd. 175 (2023), Artikel 116852

CoNiCrMo particles, but not TiAlV particles, activate the NLRP3 inflammasome in periprosthetic cells

Brunken, Fenna; Senft, Tristan; Herbster, Maria; Relja, Borna; Bertrand, Jessica; Lohmann, Christoph H.

In: International journal of molecular sciences - Basel : Molecular Diversity Preservation International, Bd. 24 (2023), Heft 6, Artikel 5108, insges. 12 S.

Damage analysis of retrieved Biolox® delta components used in hard and soft bearings

Döring, Joachim; Buchholz, Adrian; Herbster, Maria; Gehring, Jennifer; Betke, Ulf; Chodór, Paweł; Zabrzyński, Jan; Bertrand, Jessica; Lohmann, Christoph H.; Łapaj, Łukasz

In: Acta biomaterialia - [Amsterdam] : Elsevier, Bd. 158 (2023), S. 827-842

Surface integrity modification of CoCrMo alloy by deep rolling in combination with sub-zero cooling as potential implant application

Döring, Joachim; Basten, Stephan; Ecke, Martin; Herbster, Maria; Kirsch, Benjamin; Halle, Thorsten; Lohmann, Christoph H.; Bertrand, Jessica; Aurich, Jan C.

In: Journal of biomedical materials research / B - Hoboken, NJ : Wiley, Bd. 111 (2023), Heft 4, S. 946-957 [Version of Record online: 08 December 2022]

Dissertation

Failure analysis and modification of metallic alloys of contemporary arthroplasty components

Herbster, Maria; Halle, Thorsten; Bertrand, Jessica; Krüger, Manja

In: Magdeburg, Dissertation Otto-von-Guericke-Universität Magdeburg, Fakultät für Maschinenbau 2023, XXV, 153, XXVII-CIII Seiten [Literaturverzeichnis: Seite LV-XCVII][Literaturverzeichnis: Seite LV-XCVII]

2022

Abstract

Analyse von Art und Schwere der Schäden an ZTA-Keramik-Hüftimplantaten

Döring, Joachim; Buchholz, Adrian; Herbster, Maria; Gehring, Jennifer; Betke, Ulf; Bertrand, Jessica; Lohmann, Christoph H.; Łapaj, Łukasz

In: 12. Kongress der Deutschen Gesellschaft für Biomechanik (DGfB) - Köln : Deutsche Gesellschaft für Biomechanik ; Potthast, Wolfgang *1967-* . - 2022, S. 202, Artikel P26 [Kongress: 12. Kongress der Deutschen Gesellschaft für Biomechanik (DGfB), Köln, 28.-30. September 2022]

Begutachteter Zeitschriftenartikel

Microstructural modification of TiAl6V4 alloy to avoid detrimental effects due to selective in vivo crevice corrosion

Herbster, Maria; Harnisch, Karsten; Kriegel, Paulina; Heyn, Andreas; Krüger, Manja; Lohmann, Christoph H.; Bertrand, Jessica; Halle, Thorsten

In: Materials - Basel : MDPI, Bd. 15 (2022), Heft 16, Artikel 5733, insges. 26 S.

Magnetic-abrasive machining in manufacturing of medical implants

Karpuschewski, Bernhard; Kotsun, Yurii; Maiboroda, Viktor; Borysenko, Dmytro; Herbster, Maria; Sölter, Jens

In: Procedia CIRP / CIRP - The International Academy for Production Engineering - Amsterdam [u.a.] : Elsevier, Bd. 108 (2022), S. 577-582

Microstructure-dependent crevice corrosion damage of implant materials CoCr28Mo6, TiAl6V4 and REX 734 under severe inflammatory conditions

Herbster, Maria; Rosemann, Paul; Michael, Oliver; Harnisch, Karsten; Ecke, Martin; Heyn, Andreas; Lohmann, Christoph H.; Bertrand, Jessica; Halle, Thorsten

In: Journal of biomedical materials research / B - Hoboken, NJ : Wiley, Bd. 110 (2022), Heft 7, S. 1687-1704 [First published 17.02.2022]

2021

Begutachteter Zeitschriftenartikel

A novel approach for a modular taper junction in hip stems using turn-milling

Döbberthin, Christin; Herbster, Maria; Karpuschewski, Bernhard

In: CIRP journal of manufacturing science and technology / CIRP - The International Academy for Production Engineering - Amsterdam [u.a.] : Elsevier, Bd. 33 (2021), S. 256-263

Aspect ratio of nano/microstructures determines Staphylococcus aureus adhesion on PET and titanium surfaces

Meinshausen, Ann-Kathrin; Herbster, Maria; Zwahr, Christoph; Soldera, Marcos; Müller, Andreas Johann; Halle, Thorsten; Lasagni, Andrés Fabián; Bertrand, Jessica

In: Journal of applied microbiology - Oxford [u.a.] : Wiley-Blackwell, Bd. 131 (2021), Heft 3, S. 1498-1514

Effect of deep rolling on subsurface conditions of CoCr28Mo6 wrought alloy to improve the wear resistance of endoprostheses

Herbster, Maria; Harnisch, Karsten; Haberland, Eva; Kriegel, Paulina; Döbberthin, Christin; Heyn, Andreas; Döring, Joachim; Lohmann, Christoph H.; Bertrand, Jessica; Halle, Thorsten

In: Journal of the mechanical behavior of biomedical materials - Amsterdam [u.a.] : Elsevier, Bd. 118 (2021), Artikel 104398

Chondrocytes from osteoarthritic and chondrocalcinosis cartilage represent different phenotypes

Meyer, Franziska; Dittmann, Annalena; Kornak, Uwe; Herbster, Maria; Pap, Thomas; Lohmann, Christoph H.; Bertrand, Jessica

In: Frontiers in cell and developmental biology - Lausanne : Frontiers Media, Bd. 9 (2021), Artikel 622287, insges. 9 S.

Synthesis of a lubricant to mimic the biorheological behavior of osteoarthritic and revision synovial fluid

Herbster, Maria; Nizinkovskyi, Rostyslav; Bollmann, Miriam; Bartel, Dirk; Lohmann, Christoph H.; Krüger, Manja; Halle, Thorsten; Bertrand, Jessica

In: Lubricants - Basel : MDPI, Bd. 9 (2021), Heft 9, Artikel 87, insges. 20 S.

2020

Begutachteter Zeitschriftenartikel

Microstructure and surface investigations of TiAl6V4 and CoCr28Mo6 orthopaedic femoral stems

Herbster, Maria; Harnisch, Karsten; Baierl, Toni; Rosemann, Paul; Lohmann, Christoph H.; Bertrand, Jessica; Halle, Thorsten

In: IOP conference series / Materials science and engineering / Institute of Physics - London [u.a.] : Institute of Physics - Vol. 882.2020, Paper 012004, insgesamt 16 Seiten [Symposium: Symposium on Materials and Joining Technology, Magdeburg, Germany, 7-8 September 2020]

Intraoperative assembly of anatomical shoulder prosthesis frequently results in malalignment of the modular taper junction

Herbster, Maria; Berth, Alexander; Märtens, Nicole; Robra, Marcel; Welzel, Florian; Dallmann, Frank; Lohmann, Christoph H.; Halle, Thorsten; Bertrand, Jessica; Döring, Joachim

In: Journal of orthopaedic research - Hoboken, NJ [u.a.] : Wiley, Bd. 39 (2021), Heft 11, S. 2485-2496

Retrieval study of commercially available knee implant coatings TiN, TiNbN and ZrN on TiAl6V4 and CoCr28Mo6

Herbster, Maria; Döring, Joachim; Nohava, Jiri; Lohmann, Christoph H.; Halle, Thorsten; Bertrand, Jessica

In: Journal of the mechanical behavior of biomedical materials - Amsterdam [u.a.] : Elsevier - Vol. 112.2020, Art.-Nr. 104034

In vivo corrosion and damages in modular shoulder prostheses

Herbster, Maria; Märtens, Nicole; Harnisch, Karsten; Berth, Alexander; Döring, Joachim; Lohmann, Christoph H.; Halle, Thorsten; Bertrand, Jessica

In: Journal of biomedical materials research / B - Hoboken, NJ : Wiley, Bd. 108 (2020), Heft 5, S. 1764-1778

2019

Abstract

Ex vivo Schadensanalyse an Konussteckverbindungen aus Co28Cr6Mo- und Ti6Al4V-Legierungen von anatomischen Schulterendoprothesen

Herbster, Maria; Märtens, Nicole; Halle, Thorsten; Lohmann, Christoph H.; Bertrand, Jessica

In: WW WerkstoffWoche , 2019 - Sankt Augustin : Deutsche Gesellschaft für Materialkunde e.V. [Konferenz: Werkstoffwoche 2019, Dresden]

Corrosion at modular taper junctions in anatomical shoulder prosthesis - a retrieval study

Herbster, Maria; Märtens, Nicole; Halle, Thorsten; Lohmann, Christoph; Bertrand, Jessica

In: 5th Euro BioMAT 2019 , 2019 - [Berlin : DGM e.V. - 2019, Artikel B3.2: Session 2 [Konferenz: 5th European Symposium and Exhibition on Biomaterials and Related Areas, BioMAT 2019]

Begutachteter Zeitschriftenartikel

Characteristics of different cathodic arc deposition coatings on CoCrMo for biomedical applications

Döring, Joachim; Herbster, Maria; Nestler, Christian; Welzel, Florian; Bertrand, Jessica; Lohmann, Christoph H.

In: Journal of the mechanical behavior of biomedical materials - Amsterdam [u.a.] : Elsevier, Bd. 97 (2019), S. 212-221

2018

Abstract

Differences in rheological properties between healthy, osteoarthritic and revision synovial fluid

Herbster, Maria; Halle, Thorsten; Lohmann, Christoph; Bertrand, Jessica

In: ICoBT 2018 - Montreal - 2018, Poster-ID P27 [Konferenz: 4th International Conference on BioTribology, ICoBT 2018, Montreal, Canada, 26 - 29 September 2018]

2017

Artikel in Kongressband

Tribologische Charakterisierung natürlicher und künstlicher Gelenkoberflächen

Herbster, Maria; Boccaccini, Aldo R.; Czichy, Charis; Gerth, Peter; Goldau, Harald; Lohmann, Christoph; Bertrand, Jessica

In: Reibung, Schmierung und Verschleiß ; CD-ROM: Reibung, Schmierung und Verschleiß / Tribologie-Fachtagung , 2017 - Aachen : GfT Gesellschaft für Tribologie e.V. ; Tribologie-Fachtagung (58.:2017) - 2017, Art. 43, insgesamt 7 S. [Tagung: 58. Tribologie-Fachtagung 2017, Göttingen, 25. - 27. September 2017]

Untersuchungs- und Prüfmethoden für funktionale Gelenkoberflächen

Herbster, Maria; Gerth, Peter; Goldau, Harald; Döring, Joachim; Lohmann, Christoph; Bertrand, Jessica

In: Sensitive Fertigungstechnik , 2017 - Aachen : Shaker Verlag ; Goldau, Harald . - 2019, S. 179-184 [Tagung: 4. Fachtagung "Sensitive Fertigungstechnik", 2017, Magdeburg]

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